Comparative Study of Ondansetron versus Metoclopramide for Prevention of Post Operative Nausea and Vomiting after General Anaesthesia

Patients who undergo laparoscopic cholecystectomy under general anaesthesia may be at risk of experiencing post- operative nausea and vomiting (PONV). Commonly used traditional antiemetics for PONV include the anticholinergics (Scopolamine), Phenothiazines (Promethazine), Antihistamines (diphenhydramine), butyrophenones (Droperidol) and benzamides (Metoclopramide). These antiemetics have adverse effects such as dry mouth, sedation, hypotension, extrapyramidal symptoms, dystonic effects and restlessness. The newest class of antiemetics used for the prevention and treatment of PONV are serotonin receptor antagonist (Ondansetron, Granisetron). These antiemetics do not have the adverse effects of the older antiemetics except headache and dizziness. This study compared the prophylactic intravenous use of Metoclopramide and Ondansetron for the prevention of nausea and vomiting in patients who underwent laparoscopic cholecystectomy under general anaesthesia in Nepalese population