Significance of Penetration Enhancers in Topical Drug Delivery System- A Review

Topical drug delivery is most acceptable and convenient route of administration of drug which are having short half and which are poorly soluble drugs. Along with it topical route also set to be challenging area for delivery of drug through stratum corneum. Traditionally permeation enhancers were designed to deliver drug molecules across skin into systemic circulation. Emergence of some other techniques for enhancement through modification of stratum corneum by hydration, or by using chemical or physical effects has remained area of interest. In this review, we represented an overview of the current strategies to overcome stratum corneum as a barrier for entry of drug molecule.