FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLET OF ROSUVASTATIN USING CASSIA TORA SEEDS MUCILAGE AS NATURAL SUPERDISINTEGRANT
Journal: International Journal of Pharmaceutical Sciences and Medicine (IJPSM) (Vol.5, No. 7)Publication Date: 2020-07-30
Authors : Shalu Chouhan; G.N. Darwhekar; Ashish Gupta;
Page : 16-38
Keywords : Orodispersible Tablet; Rosuvastatin; Superdisntegrants; Cassia tora seeds; Solubility;
Abstract
The present research work was to develop the preparation of orodispersible tablet of Rosuvastatin by Direct compression method using different concentration of Cassia tora seeds mucilage as natural superdisintegrants. A two-factor-three-level (3 2) factorial design is being used to optimize the nine formulation batches (F 1-F 9) were prepared accordingly. Two factors as independent variables (X 1-amount of β-cyclodextrine and X 2-amount of cassia tora seeds mucilage) were taken with three level (+1, 0,-1). The in-vitro drug release, Disintegration time and wetting time used as dependent variable (Response). All the active blends were evaluated for precompression parameters and the tablets were evaluated for post compression parameter (weight variation, Hardness, Thickness, Friability, Disintegration time, Drug content, wetting time, water absorption ratio and in-vitro drug studies). It was found that the drug:β-cyclodextrine inclusion complex leads to improved the dissolution characteristics and solubility of drug at optimum concentration (1:5) but as the concentration of Cassia tora seeds mucilage powder that significant effect on disintegration characteristics as well as drug release but the higher concentration of mucilage had negative impact on drug release & disintegration time. So, considered the result, it was found that the formulation F6 was found to be optimized formulation. It was observed from the F 6 which showed the disintegration time 26.05±0.249 sec and percentage cumulative drug release showed 96.8±0.629 % within a 15 minutes.
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Last modified: 2020-07-11 22:30:19