Enzymatic Synthesis of Nigellidine & Nigellicine by the Heterocyclic Rings of Pyrazole and Indazole Ring Systems

The arena of synthetic organic chemistry has advanced greatly from the various current advances in selective C–H functionalization. Undeniably, chemical oxidations of C–H bonds areof the furthermost important transformations in synthetic chemistry since they agree for direct contact to oxidized intermediates, without the need for synthetic handles or functional group interconversions.Despite recent advances, there remain significant limitations regarding the regioselectivity of non-directed C–H oxidation reactions. Since N.sativa L. acts as awide variety of pharmacological actions discussed previously and updated in this report, interest has arisen in the total synthesis of the alkaloids isolated having the isoquinoline and indazole motifs. The methanolic extract of the seeds contain two types of alkaloids whilst the major principal active ingredient isolated from the volatile oil ofN.sativa L. is TQ. The alkaloid isoquinoline comprise nigellicimine & nigellicimine-N-oxide, the indazole alkaloids encompass nigellidine and nigellicine.