DESIGN AND EVALUATION OF CHITOSAN-HPMC POLYMERIC FILMS FOR TRANSDERMAL DELIVERY OF CAPTOPRIL
Journal: Indian Drugs (Vol.57, No. 06)Publication Date: 2020-06-28
Authors : Rajesh Sreedharan Nair; Balamurugan Manickam; Teng Meng Sheng;
Page : 69-72
Keywords : * For Correspondence E-mail: Rajeshsreedharan.nair@monash.edu;
Abstract
Drug permeation through the skin layers remains a major challenge in transdermal drug delivery. In this study, the permeation enhancing property of chitosan together with its rate-controlling property has been utilized in the development of an efficient transdermal delivery system, using captopril as a model drug. Chitosan-hydroxypropyl methylcellulose (HPMC) films were developed by solvent evaporation technique. The films were characterized for appearance, thickness, weight uniformity, drug content, folding endurance and moisture absorption. Drug-polymer interaction was assessed using ATR-FTIR spectroscopy and Differential Scanning Calorimetry. The in vitro permeation carried out in Franz-type diffusion cells using synthetic Strat-M® membrane, demonstrated that the film coded F2 (Chitosan:HPMC = 50:50) showed a significant increase in drug permeation than F1 (Chitosan:HPMC = 90:10) with a flux value 86.7 µg/cm2/h. The physicochemical characterization and the stability studies confirmed that the formulated films were chemically and physically stable.
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