Formulation, Development and Evaluation of Sustained Release Matrix Tablet of Tramadol Hydrocholoride Using Various Hydrophilic Natural Polymers

The main objective of this research work was formulation, develop and evaluation of sustained release matrix tablets of Tramadol Hydrochloride using various hydrophilic natural polymers like acacia, Xanthan gum and gum of tragacanth as non-toxic, easily available and suitable matrix system. Sustained release tablet of Tramadol Hydrochloride were prepared by direct granulation method using different concentrations of hydrophilic natural polymers. The prepare tablet were evaluated for pre- compression such as Bulk density, Tapped density, the angle of repose, Carr's compression index, Hausner ratio and post-compression parameter's such as weight variation, hardness, thickness, friability, drug content, uniformity of drug and in-vitro dissolution studies. FTIR studies shown there was no interaction between drug and polymer. In-vitro drug release using USP dissolution apparatus. The dissolution study revealed that formulations containing the tragacanth as a polymer showed the drug release up to 12 hours and found to be most promising polymer among three polymers used in the research work