Anti Ulcer Activites of Hydro-Alcoholic Extract of Trigonella foenum-graecum in Different Experimentally Induced Ulcer Models in Rats

— The aim of the study was to determine antiulcer activity of whole plant of Trigonella foenum-graecum L on the albino wister rats. Dried whole plant of Trigonella foenum-graecum L was powdered and this coarse powder was extracted with 70% ethanol by soxhlet extraction method to yield an ethanol extract of whole plant of Trigonella foenum-graecum L. The extract was subject to preliminary phytochemical analysis and was evaluated for antiulcer activity against various models such as pylorus ligation, Swimming stress induced and Aspirin induced ulcer models. In acute toxicity study, HATFG was found to be safe till 2000mg/kg. So the doses of HATFG at various concentration of 200 and 400mg/kg body weight was administered orally for prevention of ulcer from Pylorus ligation, Swimming stress and Aspirin induced ulcers. Analytical parameters like percentage of ulcer protection was calculated based on ulcer index and gastric juice volume, pH, Total and free acidity of gastric juice. Preliminary phytochemical analysis of HATFG showed the presence of carbohydrates, amino acids, lipids, alkaloids, flavonoids, tannins, saponins, cardiac glycosides, steroids, and terpenoids. The HATFG has shown significant activity at both 200mg/kg and 400mg/kg dose level in a dose dependent manner. Phytochemicals like tannins, flavonoids and saponins may be responsible for anti ulcer activity of HATFG