EXPERIMENTAL MODELING OF FROSTBITES OF VARYING SEVERITY IN LABORATORY ANIMALS. Part 1. Development and technical characteristics of devicesJournal: Journal of the Grodno State Medical University (Vol.18, No. 6)
Publication Date: 2020-12-31
Authors : Valentyukevich A. L.; Melamed V. D.; Ostrovsky А. А.;
Page : 722-726
Keywords : devices; frostbites; cold injury; experiment; rats;
Background. In modern medicine, the problem of treating frostbite remains relevant and requires further study. It raised the need for a reliable experimental model of cold injury. Purpose of the study. Creation of devices that allow simulating both contact frostbites and their combination with general hypothermia in laboratory animals. Material and methods. In laboratory rats under ether anesthesia, frostbite simulation was performed using different types of devices. The depth and prevalence of cold injury were studied. Results. The existing methods of modeling frostbites are analyzed. A device has been developed for reproducing cold tissue damage in the interests of the tasks set by the experiment. Conclusions. The developed devices for simulating frostbites can be used by researchers to study topical issues of cold injury.
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