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Possibilities of Decolonization Targeting Carriers of Multidrug-Resistant Gram-Negative Bacteria (MDR-GNB) in the Gut

Journal: Acta Microbiologica Bulgarica (Vol.36, No. 3)

Publication Date:

Authors : ;

Page : 75-78

Keywords : multidrug-resistant Gram-negative bacteria (MDR-GNB); faecal microbiota transplantation; immunocompromised patients;

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Intestinal carriage of extended spectrum β-lactamase Enterobacteriaceae (ESBL-E) and carbap¬enemase-producing Enterobacteriaceae (CPE) can persist for a long time (Huttner et al., 2019). Multi¬drug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa and their intestinal carriage is also a big problem, because studies in the last years have shown that the colonization with multidrug-resistant Gram-negative bacteria (MDR-GNB), especially in immunocompromised patients, increases the risk of infections (Tacconelli et al., 2019). Therefore, the evaluation of decolonization regimens with oral antibi¬otics and faecal microbiota transplantation (FMT) used for eradication of MDR-GNB in the gut is of great importance in reducing morbidity and mortality in these patients.

Last modified: 2021-02-05 02:59:02