Comparison of The Outcome of IVF Cycles Between Poor Ovarian Responders and Unexplained Infertility Patiens/IVF Sonuçlarının Zayıf Over Yanıtı Olan Hastalar ile Açıklanamayan İnfertilite Olan Hastalar Arasında Karşılaştırılması

The aim of this research was Compare of the oucome of IVF cycles in poor ovarian reserve (POR) patients with the unexplained infertility group with normal ovarian reserve. IVF results of 488 patients who applied to the German hospital IVF center between 2012 and 2014 for infertility were retrospectively analyzed. Of these, 292 cases were included in the POR group and 192 cases in the unexplained infertility group. Female age, hormonal parameters, oocyte counts, embryo development levels and clinical pregnancy rates were evaluated. The mean female age, duration of infertility, basal FSH value, duration of ovulation induction, and dose of gonadotropins used were found to be higher, and AMH level, antral follicle count and E2 value on the day of hCG administration were lower in POR cases compared to unexplained infertility cases (p <0.001). Body mass index, basal LH value, basal E2 value were similar in both groups. Sperm parameters did not differ between groups. In the POR group, the number of oocytes collected, the number of mature oocytes, and the number of Grade I and Grade II embryos were significantly lower than the unexplained infertility group (p <0.001). The clinical pregnancy rate was significantly lower in the POR group (19.6%) than in the unexplained infertility group (33.6%) (p <0.01). In Conclusion patients with poor ovarian reserve, the number of mature oocytes, day 3 embryos and clinical pregnancyrate are lower in an IVF cycle compared to patients with normal reserves.