Method for Determining the Radiochemical Purity of Radiopharmaceuticals Based on Iodine-125, Iodine-131 and Samarium-153-oxabifor

Radionuclides 125I, 131I and 153Sm are used to obtain labeled radiopharmaceuticals used in medicine for diagnostics, treatment, and anesthesia in various diseases. Radionuclide 125I was obtained by irradiation with neutrons of the enriched isotope 124Хе in a nuclear reactor. 131I was isolated from irradiated samples of TeO2 enriched in 130Те, and radionuclide 153Sm was obtained by irradiation of samples 152Sm2O3 in a nuclear reactor. The radiochemical purity of sodium iodide preparations labeled with 125I or 131I radionuclides was determined by the electrophoretic method, and the samarium-153-oxabifor preparation was determined by ascending paper chromatography. To determine the distribution of the activity of 125I, 131I, and 153Sm-oxabiphor by electrophoregrams and chromatograms, a γ-radiometric device Ludlum-2200 was used, which makes it possible to determine the radiochemical purity at the level of 99.9%.