Design, Synthesis and Antimicrobial Activity Evaluation of New Bisimidyl Sulfonamido Ketone Comprising Drug component
Journal: Chemical Methodologies (Vol.5, No. 6)Publication Date: 2021-11-01
Authors : Zaynab Hussein Fadel; Ahlam Marouf Al-Azzawi;
Page : 464-470
Keywords : β -lactam containing drugs; bis [N-phenyl phthalamic acid] ketone; cyclic imide; Sulfonamido group;
Abstract
This work involved design and synthesis of four new compounds which their molecules contain three biologically active segments, including β-lactam containing drug, cyclic imide and sulfonamido group. Synthesis of the compounds was performed by several steps. In the first step, compound (1) bis[N-phenyl phthalamic acid] ketone was synthesized via reaction of aniline with benzophenone 3,3’,4,4’-tetra carboxylic dianhydride. In the second step, compound (1) was dehydrated by fusion to give the corresponding bis phthalimide (2) which in turn was introduced in reaction with chloro sulfonic acid. The third step involved producing compound (3), the corresponding bis phthalimidyl benzene sulfonyl chloride. Compound (3) is the important key compound from which the target compounds (4-7) were prepared through its reaction with different β-lactam containing drugs. Antibacterial and antifungal activities of compounds (4-7) were screened and the results indicated that they have high biological activity.
Other Latest Articles
- Chemical Composition and Insecticidal Activities of Mentha Longifolia and Mentha Mozaffarianii Essential Oils against Callosobruchus Maculatus
- DOMAIN SPECIFIC AUTOMATED ESSAY SCORING USING CLOUD BASED NLP API
- Mechanisms of public management of innovative development of employment of the population of Ukraine
- State regulation of innovative development of the educational industry on the basis of strategic management
- The new essence of management culture – an important value of change policy in Ukraine
Last modified: 2021-10-22 20:32:46