Antioxidant & Anti Inflammatory Activity Of Magnesium Oxide Nanoparticles - An In vitro study

Introduction: Magnesium oxide (MgO) is an important inorganic material & has shown a promising role for applications in medicine. MgONPs have unique properties like high chemical stability, high photo catalytic activity and non-toxic nature. Aim: The aim of the study was to evaluate the antioxidant and anti inflammatory activity of magnesium oxide nanoparticles (MgONps) using Phyllanthus emblica fruit extract. Materials and Methods: MgONPs were synthesised using Phyllanthus emblica fruit seed extract, and antioxidant & anti inflammatory activity of synthesized MgONPs were assessed using DPPH radical assay & by Albumin denaturation assay. Result and Discussion: The plant extract color was green and when it reacted with magnesium nitrate solution it changed to brown color which indicated the synthesis of MgONPs. The MgONPs have a characteristic band in the ultraviolet visible (UV) region due to their surface plasmon resonance. The peak was at a wavelength of 385.0 nm. DPPH assay was used to evaluate the antioxidant activity of newly synthesized nanoparticles and it showed good antioxidant activity.Albumin Denaturation assay was used to evaluate the anti inflammatory activity of newly synthesized nanoparticles and the results showed excellent anti inflammatory activity. Conclusion: Biosynthesised MgONPs showed promising results for biomedical applications. Hence, it may be employed in large scale production and may be used in many medicinal applications