Influence of the Formulation and Preparation Technique on the Flufenamic Acid Release from Different Collagenic Supports Designed for Wound Healing

Drug delivery systems with controlled release are one of the top applications for human health, a new domain in material science with biomedical application. The aim of this study was to obtain and characterize some drug delivery systems based on collagen, dextran and flufenamic acid (matrices, membranes and fibers) for wound healing. The samples were analyzed by FT-IR and in vitro release of flufenamic acid. From the FT-IR spectra it can be seen that collagen macromolecule keeps its triple helix structure. The percentage of drug delivered is influenced by the degree of cross linking, the presence of dextran in the designed formulations and the collagen support preparation technique.