Antibacterial and Immuno Modulatory Roles of Ocimum Gratissimum in the Control of E. coli O157 H7 Chicken Colibacillosis

O. gratissimum is one of the leafy vegetables used by Nigerians as a food additive in preparing some local dishes. It has also been documented by some researchers to have some medicinal values. This research aimed at monitoring the immunomodulatory and antibacterial roles of Ocimum gratissimum ethanolic extract in the control of colibacillosis in broilers as a natural alternative to antibiotic therapy.1.5 ml 107 cfu ml E. coli O157 H7 isolated from nono sour milk and identified with 16s rDNA sequencing, was used to elicit colibacillosis infection in three weeks old broilers. Oral administration of the plant extract 40 g l to the infected birds over a 1 month period resulted in regulated haemoglobin, blood electrolytes, urea, creatinine, C reactive protein and liver enzyme values. Microbial counts in the intestine revealed a decrease in total E. coli count. Histopathology examination of the intestinal tissues revealed the activity of gut associated lymphoid tissue in immune response. O. gratissimum ethanolic extract can serve as a natural alternative to antibiotic therapy in the control of colibacillosis in broilers. Ikele, O. M. | Ezeonu, I. M. | Umeoduagu, N. D. "Antibacterial and Immuno-Modulatory Roles of Ocimum Gratissimum in the Control of E. coli O157:H7 Chicken Colibacillosis" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-6 , October 2022, URL: https://www.ijtsrd.com/papers/ijtsrd51930.pdf Paper URL: https://www.ijtsrd.com/biological-science/microbiology/51930/antibacterial-and-immunomodulatory-roles-of-ocimum-gratissimum-in-the-control-of-e-coli-o157h7-chicken-colibacillosis/ikele-o-m