COMPARATIVE EVALUATION OF N-ACETYLCYSTEINE AND DEXAMETHASONE EFFECTS ON THE CLINICAL COURSE OF UVEITIS IN AN EXPERIMENT
Journal: Journal of the Grodno State Medical University (Vol.20, No. 6)Publication Date: 2023-01-13
Authors : V. G. Marmysh;
Page : 593-598
Keywords : experimental immunogenic uveitis; clinical signs; N-acetylcysteine; dexamethasone;
Abstract
Objective. To evaluate and compare the effects of the parenteral administration of N-acetylcysteine (NAC), dexamethasone and their combination on the clinical course of experimental immunogenic uveitis (EIU). Material and methods. The experimental study was carried out on 72 rabbits (144 eyes), eight of which were intact. The animals with EIU were divided into 8 groups (8 in each), which received parenteral injections of placebo, NAC, dexamethasone or a combination of NAC and dexamethasone and were withdrawn from the experiment on the 3rd or 7th day. A clinical assessment of the uveitis course by external examination and biomicroscopy was performed on the 3rd and 7th day. The severity of clinical signs of uveitis was estimated in score points according to 7 criteria. Results. NAC parenteral administration led to a significant improvement in the clinical picture of EIU. Dexamethasone had a stronger anti-inflammatory effect comparing to NAC. The combination of NAC and dexamethasone showed pharmacological synergy of action, which made it possible to increase the effectiveness of therapy. Conclusion. 1. Parenteral administration of NAC significantly reduces the intensity of the local inflammatory reaction in EIU. 2. NAC and dexamethasone have a mutually potentiating pharmacological effect, which can significantly increase the effectiveness of anti-inflammatory therapy of EIU. 3. The results of the study serve as an objective justification for the inclusion of NAC in the complex therapy of uveitis, in particular in combination with dexamethasone.
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