Formulation and evolution of oral osmotic pump based controlled delivery of Lornoxicam

Background: Osmotic devices are the most reliable controlled drug delivery systems (CDDS) and can be employed as oral drug delivery systems. Methods: Osmotic pressure is used as the driving force for these systems to release the drug in a controlled manner. Drug delivery from these systems is not influenced by the different physiological factors within the gut lumen. The main objective of this is to formulate ODDS for Lornoxicam that can provide prolonged effect to better patient compliance. Lornoxicam is a NSAID agent. ODDS formulations of Lornoxicam were prepared using different concentrations of Tris amino buffer and sodium chloride, by wet granulation technique. The tablets were coated with cellulose acetate in an automated perforated pan (Ganscoater, India). Tablet thickness, hardness, weight variation and drug content analysis, drug release study were performed. Results: The increase in osmoagent content, rate of drug release were found to be increasing an optimum concentration of osmoagent and to give a zero order release was identified