Effect of Dissolution Medium on Mouth Dissolving Tablets of Aceclofenac

Background: The goal of the present research work was to formulate and evaluate fast dissolving tablets and to investigate the effect of dissolution medium. Aceclofenac is a non steroidal anti inflammatory drug, mainly used for treatment of arthritis and is absorbed 50% orally. The drug undergoes hepatic metabolism, so the attempt has been made to administer it as mouth dissolving tablet to increases its oral bioavailability and fast on set of action. Method: Four different formulations of the tablets were prepared by using direct compression method using superdisintegrants (Cross povidone, Cross carmellose sodium). The tablets were evaluated for hardness, weight variation, wetting time, water absorption ratio, in vitro disintegrating time and in-vitro dissolution study was performed in pH 6.8 phosphate buffer and pH 1.2 (0.1N HCl). Results: Formulation F2 showed rapid disintegration time (9 Sec) compared to other formulations. Low percentage of drug release of aceclofenac in pH1.2 (0.1 N HCl), which was improved in the presence of sodium lauryl sulphate (1%), it is 33.45 % - 86.58 % from the initial release of 1.02 % to 2.52 %. It was concluded that the tablets have better disintegrating properties and release profile when compared to the tablets of conventional tablet. The in vitro drug release profile of the optimized formulation (F2) was compared with marketed conventional tablet (Acelome), the release only 62.6 % of the drug in 30 min where as the F2 formulation released up to 101.4 %. Conclusion: Thus conclusion can be made that the stable mouth dissolving tablets of aceclofenac can be developed for the rapid release of aceclofenac.