Post-Treatment Of ISO-1 Attenuates the Expression of MIF And Inflammatory Response to Influenza A (H9N2) Infection on A549 Cells |Biomedgrid

H9N2 Avian influenza viruses generally cause mild to moderate infections, and occasionally cause clinical respiratory diseases in humans. Macrophage Migration Inhibitory Factor (MIF), has been evaluated as a pro-inflammatory cytokine, anterior pituitary-derived hormone, and glucocorticoid-induced immune-modulator, associated with inflammatory and immunology reactions of lung diseases. ISO-1[(S, R)-3-(4- hydroxyphenyl)-4-5-isoxazole acetic acid methyl ester] is a specific antagonist of macrophage Migration Inhibition Factor (MIF). The question, whether ISO-1-treatment could modulate the inflammatory response induced by H9N2 avian influenza virus, is unclear. This study was undertaken to investigate the chemokine /cytokine response to influenza A infection by post-treatment of ISO-1 on human lung alveolar epithelial cells (A549 cells).