Investigating the Link Between Alzheimers Disease and Type 2 Diabetes Mellitus

Within the body, enzymes play an essential role in maintaining the homeostasis. Inadequate actions of enzymes are linked to several illnesses. The primary attention on IDE as a protease enzyme involved in the degradation of insulin hormone and then has extended in last 20 years due to its numerous unique characters of the enzyme in relations to structure, function and sub cellular localization. Now evidence gradually supporting the idea that IDE might be participating in the human diseases pathogenesis like AD or T2DM. AD and T2DM are linked by the accumulation of protein aggregates called as amyloid fibrils. Despite the absence of sequence similarity between amyloidogenic proteins, all amyloid fibrils share a usual morphology, all have a ß-sheet structure and are unsolvable in physiological situations and are uninfluenced by proteolytic degradation. Thus, cells evolutionary developed systems to degrade amyloidogenic species before their accumulation. Molecular chaperones are one example of such system they help proper protein folding and stop the accumulation of misfolded proteins. Ashfaq Ahmad "Investigating the Link Between Alzheimer's Disease and Type 2 Diabetes Mellitus" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-7 | Issue-4, August 2023, URL: https://www.ijtsrd.com/papers/ijtsrd59810.pdf Paper Url:https://www.ijtsrd.com/other-scientific-research-area/other/59810/investigating-the-link-between-alzheimers-disease-and-type-2-diabetes-mellitus/ashfaq-ahmad