FORMULATION AND EVALUATION OF METFORMIN ORODISPERSIBLE TABLETS

His study , the effect of using variable quantity of disintegrat ing agents like Crossceramilose sodium, Crospovi done, Sodium Starch Glycolate on the mouth dissolving property of Metformin tablets. Total five formul ations in triplicate havin g disintegrants at variable amount were prepared by direct comp ression method. The tablets, were assessed if suitable as oral disintegrating tablets by determination of a range of technological parameters. Tablets were prepared by direct compression method and evaluated for hardness, thickness, friability, disintegrat ion time, and percentage of drug release. It was observed that the formulation containing SSG were have better disintegrating property compared to othe r. Hardness of the tablets was found to be in the range of 3.4 ‐ 3.9 kg/cm 2 for all formulations. The wetti ng time d ecreased with the increase in concentration of disintegrants. The tablets showed 97.52 ± 0.46 % to 100.56 ± 0.3 2 % of the labeled amount of drug, indicating uniformity in drug content . The in vitro dissolution time of various formulations was between 26.6 ±1.22 secs to 45.6±2.57 sec s . Keywords: Orodispersible tablets, Crospovidone, Sodium starch glycolate, Super disintegrants