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SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF CHALCONES, PHENYLPYRIMIDINES DERIVATIVES BEARING DIBENZO [B,F][1,4]THIAZEPINES

Journal: International Journal of Advanced Research (Vol.12, No. 02)

Publication Date:

Authors : ; ;

Page : 144-152

Keywords : Chalcones Phenylpyrimidin Heterocyclic Compounds Thiazepine Derivatives Antimicrobial Activity;

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Abstract

Chalcones, Phenylpyrimidines derivatives showed remarkable therapeutic activity, with a view of getting to synthesis11-chlorodibenzo[b,f][1,4]thiazepine (1), 1-(4-(dibenzo[b,f][1,4]thiazepin-11-yloxy)-3-methoxyphenyl)ethan-1-one (2),(E)-1-(4-(dibenzo[b,f][1,4]thiazepin-11-yloxy)-3-methoxyphenyl)-3-(4-aryl)prop-2-en-1-ones(3a-3j) &4-substituted-6-(4-(dibenzo[b,f][1,4]thiazepin-11-yloxy)-3-methoxyphenyl)pyrimidin-2(1H)-ones (4a-4j) have been synthesized, All the synthesized compounds were characterized by TLC, IR, 1H NMR, Mass spectral data. All the synthesized compounds (3a-3j) & (4a-4j) were screened for their antimicrobial activity at 40 µg/ ml concentration.

Last modified: 2024-02-27 15:17:10