Synthesis, Molecular Docking, and Biological Evaluation of Some New Naphthalene-Chalcone Derivatives as Potential Anticancer Agent on MCF-7 Cell Line by MTT Assay

Naphthalene chalcones (3a-i) with excellent yields were achieved through the use of aromatic ketones, 1-naphthaldehyde, and aqueous NaOH in the synthesis process. The synthesized chalcones were bio-evaluated as potential tubulin polymerization inhibitors for the treatment of breast cancer. The antiproliferative potential of each synthesized compound against the MCF-7 cell line was assessed. The majority of the compounds showed strong antiproliferative properties. With an IC50 value of 222.72 µg/mL, compound 3f exhibited the most antiproliferative activity among them, surpassing that of 5FU (IC50, 51.47 µg/mL).