The Liquid Technique: A Novel Approach to Improve the Solubility and Bioavailability of Insoluble Drugs

The purpose of this review is to elucidate how a liquisolid system may enhance the bioavailability as well as dissolving rate of less soluble medications. A variety of techniques, including complexation, solid dispersion, ball milling, crystal engineering, and Drug delivery systems that self-emulsify have been used. in recent research to improve drug solubility; nevertheless, liquisolid compacts have shown superior results in terms of increasing dissolution. These days, a lot of medications on the market have less solubility, which causes less dissolution and bioavailability. As a result, soluble is starting to slow down the development of new medications. There are other approaches to solving this issue; however, the most promising approach is the liquisolid technique, which is covered in this article. Spireas et al.'s novel mathematical model serves as the foundation for this technique. The majority of a liquid solid is made up of a drug, a non-volatile solvent, a carrier material, a coating material, and a disintegrant.