Hypoxic effects in extreme stressful conditions: some research technologies for improving health and longevity

Aim. Description of some technologies of many years of research and their results in the age aspect in extreme situations (such as hypoxia), application of these technologies to improve the survival of organisms in stressful situations, their treatment and rehabilitation, as well as longevity. Methods. Numerous observations on changes in biometric indicators in the comparative-age aspect of individuals in extreme highland conditions using standard methods of laboratory analysis of bioindicators in mountain conditions were analyzed. The digital indicators input to databases; mathematical, program modeling were used. Results. The data on observations and measurements of various physiological characteristics of people, presented in a comparative age aspect, are presented. The influence of high-altitude factors on the longevity of bioorganisms, as well as some problems in aging physiology and hypoxic states, is described. The results of examinations of veteran climbers regarding adaptation to hypoxic barium, active gradual (stepwise) adaptation, the hypoxic therapy method, and combinations of these methods are discussed. A mathematical model of ischemic heart disease is presented, and technologies for the survival of people of different ages under extreme, stressful conditions are developed. Conclusion. During the study of age-related aspects of adaptation to hypoxybaria, it was found that it increases the organism's performance, its resistance, protects against premature aging, and promotes longevity. With age, the organism's ability to adapt to hypoxia decreases but is not entirely lost — older people can adapt up to 5000 m a.s.l. The results of a survey of veteran mountain climbers regarding adaptation to hypoxic media using a number of developed technologies are presented. The results of mathematical modeling are demonstrated. Obtained results are essential for the further development of technologies for the survival of human of different ages in extreme, stressful conditions, their treatment, and rehabilitation.