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Hepatoprotective Activity of Methanol Extract of Melastoma malabathricum Leaf in Rats
Journal: Journal of Acupuncture and Meridian Studies (Vol.6, No. 1)Publication Date: 2013-02-28
Authors : Farah Hidayah Kamisan; Farhana Yahya; Noor Aisyah Ismail; Syafawati Shamsahal Din; Siti Syariah Mamat; Zalina Zabidi; Wan Noraziemah Wan Zainulddin; Norhafizah Mohtarrudin; Hadijah Husain; Zuraini Ahmad; Zainul Amiruddin Zakaria;
Page : 52-55
Keywords : hepatoprotective activity; in vivo; leaves; Melastoma malabathricum; Melastomaceae; methanol extract;
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Abstract
The present study aimed to determine the hepatoprotective activity of a methanol extract of Melastoma malabathricum leaves (MEMM) using two established rat models. Ten groups of rats (n=6) were given a once-daily administration of 10% dimethyl sulfoxide (negative control), 200mg/kg silymarin (positive control), or MEMM (50, 250, or 500mg/kg) for 7 days followed by induction of hepatotoxicity either using paracetamol or carbon tetrachloride. Blood samples and livers were collected for biochemical and microscopic analysis. Based on the results obtained, MEMM exhibited a significant (p
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