UNDERINVESTIGATED ROLES OF GLUCOSE-6-PHOSPHATE DEHYDROGENASEJournal: Journal of Vasyl Stefanyk Precarpathian National University (Vol.2, No. 1)
Publication Date: 2015-03-01
Authors : DMYTRO GOSPODARYOV;
Page : 25-37
Keywords : NADPH; superoxide; thiol; iron-sulfur cluster; glutathione.;
The review examines certain aspects of the reaction catalyzed by glucose-6-phosphate dehydrogenase (G6PDH) in living organisms of different taxa, from bacteria to humans. Particular emphasis is put to the role of G6PDH in iron homeostasis and lipogenesis. Prooxidant and antioxidant roles of G6PDH are also highlighted along with several currently known mechanisms of G6PDH regulation.
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