CONTENT OF DOPAMINE, NORADRENALINE AND THEIR PRECURSOR DIHYDROXYPHENYLALANINE IN THE BRAIN OF RATS UNDER THE LONG-TERM INFLUENCE OF OXYETHYLIZED NONYLPHENOLS AND THEIR DERIVATIVES

Aim. The purpose of the study was an estimation of the longterm influence of oxyethylized nonylphenols and their derivatives in doses 1/10, 1/100 and 1/1000 DL50 on the content in the brain of rats of monoamines - dopamine, noradrenaline and their precursor dihydroxyphenylalanine. Material and Methods. The content of dihydroxyphenylalaÂÌ nine, dopamine, noradrenaline in the homogenate of the brain of rats was determined by chromatographic and spectrofluorometric methods on 45th day of the influence of oxyethylized nonylphenols and their derivatives in doses 1/ 10, 1/100 and 1/1000 DL50, which is necessary for discovery of pathophysiological mechanisms of their action. Results and Discussion. Nonylphenols with 6 and 12 oxyethylized groups and their derivatives - sodium salts of carboxymethylates of oxyethylized isononylphenols with 4 and 6 oxyethylized groups in a dose 1/10 DL50 decrease the content of dihydroxyphenylalanine, noradrenaline against the rise of dopamine in the brain of rats. The substances in a dose 1/100 DL50 increase the level of dopamine, noradrenaline against the unchanged content of dihydroxyphenylalanine. The dose of substances 1/1000 DL50 does not affect the examined indexes. Conclusions. The results suggest that the long-term influence of substances in a dose 1/10 DL50 leads to a decrease of monoaminergic activity of the brain of rats. The long-term influence of substances in a dose 1/100 DL50, inversely, causes its strengthening, that allows considering it as a protective and compensatory reaction of the body. Key words: oxyethylized nonylphenols, rats, brain, dihydroxyphenylalanine, dopamine, noradrenaline