VALPROIC ACID INDUCED HYPERAMMONEMIC ENCEPHALOPATHY
Journal: Indo American Journal of Pharmaceutical Sciences (IAJPS) (Vol.2, No. 9)Publication Date: 2015-09-12
Authors : Ansu Anna Dan; Josna James; Anjali George; Unnimaya Premkumar; Apollojames; T.R.Ashok Kumar; T. Sivakumar;
Page : 1248-1250
Keywords : lethargy; impaired consciousness; focal neurological signs;
Abstract
Valproic acid (VPA) has been used in clinical practice since 60’s, with a relatively favourable safety and efficacy profile. Pancreatitis, hepatotoxicity and teratogenicity are the most significant adverse drug reactions. VPA-induced hyperammonemia include: lethargy, impaired consciousness, focal neurological signs and symptoms and increased seizure frequency. More rare described symptoms are: aggression, ataxia, asterixis, vomiting and coma. We report a patient with migraine who developed hyperammonemic encephalopathy in association with valproic acid. The condition improved with a strike of valproic acid and the treatment with carnitine at a dose of 50mg/kg/day for four days.
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Last modified: 2015-09-12 22:35:16