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Journal: Indo American Journal of Pharmaceutical Sciences (IAJPS) (Vol.2, No. 9)

Publication Date:

Authors : ; ; ; ; ; ; ;

Page : 1248-1250

Keywords : lethargy; impaired consciousness; focal neurological signs;

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Valproic acid (VPA) has been used in clinical practice since 60’s, with a relatively favourable safety and efficacy profile. Pancreatitis, hepatotoxicity and teratogenicity are the most significant adverse drug reactions. VPA-induced hyperammonemia include: lethargy, impaired consciousness, focal neurological signs and symptoms and increased seizure frequency. More rare described symptoms are: aggression, ataxia, asterixis, vomiting and coma. We report a patient with migraine who developed hyperammonemic encephalopathy in association with valproic acid. The condition improved with a strike of valproic acid and the treatment with carnitine at a dose of 50mg/kg/day for four days.

Last modified: 2015-09-12 22:35:16