PREPARATION AND EVALUATION OF DECITABINE LIPOSMOES

The aim of this study was to Formulation and In-vitro evaluation of liposomal drug delivery system of Decitabine. Decitabine is an anticancer medication is indicated for treatment of patients with myelodysplastic syndrome (MDS). Decitabine Liposomes are prepared by the thin film hydration method using the soya lecithin as the phospholipid. This study mainly explains about the effect of concentration of soya lecithin, cholesterol and Tween 80. The prepared liposomes were characterized by scanning electron microscopic method respectively. The In-vitro release studies were performed and the drug release kinetics was evaluated using linear regression method. The objective of the present study was to develop liposome containing Decitabine and the prepared liposomes were evaluated for size, shape, drug entrapment efficiency, In-vitro drug release and stability. Decetabine loaded liposomes formulation had good ability to encapsulate drug and elicted favorable physicochemical characteristics. The intestinal absorption and antitumor capacity of Decitabine was significantly enhanced by using liposomes. These results suggest that liposomes could be a promising perioral carrier for Decitabine. Key Words: Liposomes, (MLV) multi lamellar vesicles, Thin film hydration method, Decitabine, Lecithin, Cholesterol, Tween 80.