Devolpment of New Spectrophotometric Methods for the Quantitaive Analysis of Tapentadol in Pharmaceutical Dosage Forms.
Journal: Current Pharma Research (Vol.3, No. 1)Publication Date: 2012-12-15
Authors : Ch. Deva Dasu G. Eshwar kumar E. silpa kala R. N. Shalini Mani N. S. L. Lavanya A. Krupa rao V. Srikanth P. Srinivasa babu.;
Page : 718-726
Keywords : Tapentadol; Bromothymol blue; Folin-Ciocalteu reagent.;
Abstract
Four simple, accurate, sensitive, precise and economical spectrophotometric methods have been developed for the determination of Tapentadol in the tablet formulations. The developed methods were based on the formulation of Method A is simple and direct UV spectrophotometric method and is based on determination of Tapentadol in 01N HCl, Method B is based on development of yellow chromogen due to reaction of Tapentadol diazotized sulphanilic acid, Method C id based on development of orange-red complex between Tapentadol and Method D is based on devolvement of Bromothymol blue in chloroform and blue color chromogen of Tapentadol with Folin-Ciocalteu reagent. UV spectroscopic methods with absorption maximum of 273.3nm (Method A), the yellow colored dye stuff show absorption maximum at 494.6nm (Method B), the orange-red complex shows absorption maximum at 414.6nm (Method C), and blue color chromogen shows absorption maximum at 773.3nm (Method D). The proposed methods showed good linearity in the concentration range of 5-25 μg/ml for all the methods. The results of analysis for all the methods are validated statistically by recovery studies.
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