A STUDY OF ADVERSE CUTANEOUS DRUG REACTIONS DUE TO ANTI MICROBIALS AT A RURAL BASED TERTIARY CARE CENTRE, GUJARAT

Background: Cutaneous reactions are common manifestations of adverse drug reactions. Antibiotics are not only one of the most commonly used drugs but also those which commonly causes adverse cutaneous drug reaction(ACDRs). It is very important to have detailed knowledge regarding ACDRs due to anti microbials. Objective: To find out various clinical patterns of drug reactions, common ACDR due to antimicrobials, the most common anti m icrobials responsible for it. Materials and methods: This was a cross sectional analytical study carried out in Gujarat for five years, which included all the patients with clinical diagnosis of cutaneous adverse drug reaction due to antimicrobials. It is a preformed proforma based study which included detailed clinical history, clinical examination. Results: Total of 120 patients were having ACDR due to antimicrobials. Males included 64. Most common age group was between 21 - 30 years in 26.7%patients. Most common group of antibiotic group involved was fluroquinolones in 30.8%patients. Most common drug implicated was ciprofloxacin in 15% patients. Most common pattern of ACDR was maculopapular rash in 34.2% patients. Conclusion: Antimicrobials are very commonl y prescribed drugs and various patterns of cutaneous drug reactions have been observed due anti microbials. It is very important to know regarding common culprit drug and various patterns of ACDR