CELL-CELL INTERACTIONS, THE VALUE OF VASCULAR FACTORS AND EXTRACELLULAR MATRIX IN THE DEVELOPMENT OF A BREAST TUMOR

On the basis of a literature reviews the current understandings of the genesis and the role of cell-cell interactions, vascular factors and extracellular matrix in a multi-step process of tumor progression are analyzed. Tumor progression is characterized by increased genetic damage to cells and the growth of heterogeneity of genotypic basis, increased capacity for invasion, angiogenesis, metastasis. The importance of vascular factors in the development of breast cancer is shown.