Synthesis, Structure-Parameter Correlation And Biological Evaluation Of 1-(2-Chloro-5-Nitrophenyl)-3-Phenyl-2-Propenone Compounds

A series of 1-(2-chloro-5-nitrophenyl)-3-phenyl-2-propenones were synthesized from 2-chloro-5-nitroacetophenone with various substituted benzaldehydes by crossed-Aldol condensation. The synthesized compounds have been characterized by their physical constants and spectral data. The antimicrobial activities of synthesized 1, 3-diphenyl-2-propenone compounds have been evaluated by Kirby-Baur disc diffusion method using their respective antibacterial and fungal strains.