PROOXIDANT-ANTIOXIDANT BALANCE IN THERMAL BURN OF SKIN IN EXPERIMENT AND IN CLINICAL PRESENTATION

We studied prooxidant-antioxidant balance in tissues of infant rats (lung, liver, kidney, heart) after modeling a thermal burn of 8-9% from the body surface as well as in plasma and packed red cells of 36 children of early age. The thermal trauma both in animals and children of early age leads to the increase in the activity of free radical processes: elevated levels of diene conjugates and malondialdehyde in tissues of animals and blood of children; to the reduction in the activity of α-tocopherol and catalase which demands inclusion of the medicines possessing antioxidant properties in standard therapy of a thermal burn.