THE FUNCTIONAL ACTIVITY OF PLATELETS IN FEMALE PATIENTS WITH ACUTE CORONARY SYNDROME WITHOUT ELEVATION ST, STRATIFIED BY TIMI SCALE AND GRACE

Summary. Among female patients with acute coronary syndrome without ST elevation ST, distributed into groups of low, moderate and high risk of TIMI and GRACE, platelet aggregation was studied in the spontaneous and induced state. The extent of spontaneous aggregation increased the risk of TIMI scale, and GRACE 9.4% and 9.51% in the moderate-risk group and 21.7% and 20.6% in the high-risk group, respectively (all P <0.05). Among women with acute coronary syndrome with ST segment elevation an additional factor of adverse cardiovascular events is increased spontaneous and induced functional activity of platelets. There was a significant increase in the aggregation ability by adding arachidonic acid (AA) and adenosine diphosphate (ADP). In addition, the use of an inductor ADP revealed insensitivity to the action of clopidogrel in high-risk women with acute coronary syndrome segment elevation ST. The presence of high- intensity correlations between the degree of GRACE and AA (r = 0,56; p <0.001), and ADP-induced aggregation (r = 0,61; p <0.01) and the average intensity between adrenaline- induced aggregation (r = 0.48) and between the TIMI scale, and ADP-induced aggregation (r = 0,32; p <0.05), showed patterns and relationships detected by us increased functional activity of platelets with increased risk of adverse cardiovascular events according to the TIMI predictive models and GRACE.