A possible role of progestins in fibroids growth stimulationJournal: I.P. Pavlov Russian Medical Biological Herald (Vol.3, No. 12)
Publication Date: 2001-04-15
Authors : Sidorova I.S.; Repin A.B.; Ryzhova O.V.;
Page : 72-76
Keywords : ;
Uterine fibroids is a hormone-dependent tumor. Estrogens are considered traditionally as a main stimulator of fibroids growth. However, there are many investigations which show not only estrogens but also gestagens can stimulates cell proliferation in fibroids. Progesterone modulates a mitotic activity in myometrium and fibroids nodes. Randomized clinical studies with agonists of re-leasing-hormone and hormone-replacement treatment demonstrates an ability of progestin's to stimulate fibroids growth in spite of hypoestrogenic background.
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