Indices of Immunohistochemical Markers in Women with Genital Viral Infection

The article presents the analysis of immunohistochemical markers indices in the uterine cervix tissue affected by genital viral infection. In morphogenesis and pathogenesis of cervical intraepithelial neoplasia associated with papillomavirus infection some inexplicable moments appear, namely prognosis of the development and course of disease relapses. Immunohistochemical techniques are often determinative in the diagnosis of cervical pathology. Analysis of immunohistochemical markers expression in dysplastic and neoplastic processes of cervical epithelium allow to determine the intensity of the mechanisms of proliferation, differentiation, apoptosis and malignant transformation when infected by human papilloma virus of high oncogenic risk. During an examination of reproductive age women with cervical disease of viral etiology study groups of patients were formed. Ki-67, p63 and p16INK4a markers were investigated in the women’s cervical bisopsy samples. Results of the study showed increased expression of specific antigens with the increase in cervical intraepithelial neoplasia severity. This may be the unfavorable prognostic indicator in terms of human papilloma virus infection.