3-(2,2,2-TRIMETHYLHYDRAZINIUM) PROPIONATE: THE ROLE OF ATP-DEPENDENT POTASSIUM CHANNELS IN CARDIOPROTECTION EFFECT

The work evaluated the influence of 3-(2,2,2-trimethylhydrazinium) propionate per square necrotic myocardium of the left ventricle and the level Tropоnin I serum during acute coronary occlusion (60 minutes) followed by reperfusion (90 min) in anesthetized rabbits. It is shown that distant and pharmacological preconditioning 3 (2,2,2-trimethylhydrazinium) propionate reduce necrosis zone 3 and 1,5 times, respectively. Found participation ATP dependent potassium channels (K-ATР channels) of endothelial and inducible NO-synthase in the implementation of the cytoprotective effect of distant preconditioning and 3-(2,2,2-trimethylhydrazinium) propionate, indicating that the implementation of the mechanism of pharmacological preconditioning in his cardioprotection action.