EFFECT OF AN INHIBITOR OF DPP-4-VTLDAGLIPTIN FOR THE FUNCTIONAL ACTIVITY OF P-GLYCOPROTEIN IN VIVO

In the in vivo study in rabbits the effect of vildagliptin at 5 mg / kg body weight of the functional activity of the protein transporter P-glycoprotein (P-gp, ABCB1 protein) was studied. P-gp activity was evaluated by its pharmacokinetics marker substrate - fexofenadine after a single intragastric administration. Applying vildagliptin for 14 days led to an increase in the maximum concentration of fexofenadine, its half-life, area under the concentration-time curve from zero to the last point of drawing blood, area under the concentration-time curve from zero to infinity, and the retention time of marker substrate and reduce the overall clearance rate of absorption and distribution volume, indicating that the inhibition of the functional activity of the protein transporter at the level of the whole organism.