MORPHOFUNCTIONAL CHARACTERISTICS TESTES WISTAR RATS EXPOSED TO LPS IN GIPERANDROGENEMIIJournal: I.P. Pavlov Russian Medical Biological Herald (Vol.12, No. 2)
Publication Date: 2011-06-29
Authors : S.G. Vassilievа; V.A. Mkhitarov; A.M. Kosyrevа; O.V. Makarovа;
Page : 22-27
Keywords : testis; lipopolysaccharide; giperandrogenemiya;
We investigated the morphological changes of the testes of Wistar rats with acute gram-negative ENDOTOXICOSIS against giperandrogenemii. In acute ENDOTOXICOSIS 1 st day after injection of lipopolysaccharide (LPS) showed a reduction in the level of total testosterone in serum, increase of Leydig cell nuclei and the diameters of the convoluted tubules, on the 7 th day, these figures were normalized. The introduction of LPS against giperandrogenemii recorded the most pronounced morphological changes, including significant reduction in the index of spermatogenesis, which reflects the suppression of spermatogenic function.
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