POSSIBLE WAYS OF STIMULATION OF NITRIC OXIDE PRODUCTION AS THE MAIN INDUCTOR OF ENDOTHELIAL DYSFUNCTION USING CARDIOTROPIC DRUGS IN PATIENTS WITH PERIPHERAL OCCLUSIVE ARTERIAL DISEASE

The open randomized trial meeting the ICH GCP criteria included 4 groups of patients with peripheral occlusive arterial disease, stage IIA-III according to the Fontaine classification in modification by Pokrovsky. The first group was given 5mg of nebivolol qd po, the second was given perindopril 5, 10 mg qd po, the third - L-arginine 500mg bid po during 30 days. Group 4 was a control group. After a 30-days period of conservative therapy we observed a 70% increase of NO level in the first group, 95% increase in the 2nd group and 539% increase in the 3rd. A reliable increase of nitric oxide metabolites correlated with improvement in clinical findings as well as functional tests. Treadmill test improved by 22%, 20%, and 32% respectively. Rheographic test improved in all study groups and its values exceeded the normal ones by 15-25% (P<0.05).