CHANGES IN BALANCE OF T-HELPER SUBSETS IN THE GALT OF RATS UNDER CHRONIC ZOOSOCIAL STRESS AND MODULATION OF THE INTESTINAL MICROFLORA
Journal: I.P. Pavlov Russian Medical Biological Herald (Vol.22, No. 2)Publication Date: 2014-06-27
Authors : Topol I.A.; Kamyshny A.M.;
Page : 42-48
Keywords : ;
Abstract
It was investigated the influence of chronic zoosocial stress (ZSS) and modulation of the intestinal microflora composition on the ratio of T-helper subsets in GALT. It has been established that ZSS development was accompanied by an imbalance Tbet+/Gata3+- and Foxp3 +/Roryt +-cells, indicating the dominance of Th1- and Th17-differentiation and increasing levels of pro-inflammatory signaling in the gut. It was shown that the introduction of kanamycin to the stressed rats leads to the dominance of Th1- and Treg subsets, but modulation of the intestinal microflora lactobacterine reduces the ratio of Tbet +/Gata3 + - lymphocytes in the own lamina of mucous membrane of the fibres, increases in subepithelial zone and increases unidirectionally the ratio of Treg/Th17.
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