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FUNCTIONAL ACTIVITY OF P-GLYCOPROTEIN DURING EXPERIMENTAL MANIPULATIONS
Journal: I.P. Pavlov Russian Medical Biological Herald (Vol.22, No. 2)Publication Date: 2014-06-27
Authors : Yakusheva E.N.; Shulkin A.V.; Chernykh I.V.; Titov D.S.;
Page : 74-77
Keywords : ;
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Abstract
In a study on rabbits the effect of experimental manipulations (false surgery and distilled water administration) on functional P-glycoprotein activity was studied. P-glycoprotein activity was assessed by pharmacokinetic analysis of its marker substrate - fexofenadine. Found that manipulations applied do not lead to modulation of Pgp activity at all stages of the research period.
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