EPSTEIN-BARR VIRUS ROLE IN ONCOGENESIS

We now recognize that the Epstein-Barr virus (EBV) plays a pivotal role in the development of some lymphomas and lymphoproliferative disorders that include B-cell, T-cell and NK-cell processes, and epithelial and mesenchymal tumors. While over recent years, EBV associated lymphomas are becoming increasingly recognized in patients without overt immunodeficiency. Improved understanding of the biology of these lymphomas and the role that EBV plays in their pathogenesis has paved the way for improved therapies targeted at critical signaling pathways as well as the development of novel cellular therapies. This review discusses the unique cytomorphology, clinical and immunophenotype signs and ancillary studies required to diagnose EBV-related neoplasms.