Endothelial function in patients with diabetes mellitus type 2 with arterial hypertension in good compensation of hyperglycemia

The purpose of this study was to quantify markers of endothelial function in patients with diabetes mellitus type 2 with arterial hypertension in good compensation of hyperglycemia and determining their relation to hemodynamics, renal function and lipid profile. The analysis showed that with good compensation of hyperglycemia endothelial dysfunction is formed before the appearance of clinical and laboratory signs of renal dysfunction and dyslipidemic disorders, accompanied by significant increase in the concentration of endothelin-1 (more than 4 times) and nearly 3-fold increase in the content of von Willebrand factor and thrombomodulin compared with the control group.