CHANGES INTHESPECTRUMOFABSORPTIONOFOXIDATIVE MODIFICATION OF PROTEINS IN RAT LIVER WITH SHORTAGE OF NITRIC OXIDE SYNTHESIS OF DIFFERENT EXPRESSIONS
Journal: NAUKA MOLODYKH (Eruditio Juvenium) (Vol.4, No. 1)Publication Date: 2016-03-31
Authors : S.A. TEPLOV; Y.V. ABALENIHINA; M.A. FOMINA; I.V. MATVEEVA;
Page : 50-54
Keywords : oxidative modification of proteins; L-NAME; liver;
Abstract
Influence of L-NAME in a dose of 25 and 200 mg/kg on oxidizing modification of proteins of a liver of rats is studied. It is established that when using N-nitro ? L-arginine methyl ester in a dose of 25 mg/kg the level of proteins carbonyl derivative of a liver of rats increases in comparison with control. It is important to note that the quantity of aldehyde ? and ketone-dinitropheniylhydrazons in ultra-violet area of a range statistically significantly increases that testifies to damage of the remains of the amino acids possessing neutral properties. Under the influence of L-NAME in a dose of 200 mg/kg the level of carbonyl derivative proteins of a liver of rats decreases in comparison with control that is a consequence of reduction of synthesis of nitrogen oxide. Also the increase in reserve and adaptation potential is noted that points to obvious adaptation and regenerative abilities of a liver.
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