Synthesis and Evaluation of Substituted 1, 3, 4-Thiadiazole as Potential Antimicrobial Agent

New series of N-(substituted phenyl)-2-[(5-substituted)-1,3,4-thiazol-2-yl)]acetamide (IVa-l) were synthesized by condensation of N-(substituted phenyl)-2-(5-sulfanyl-1,3,4-thiadiazol-2-yl) acetamide (IIIa-d) with different 2° amines. The structure of the synthesized compounds were characterized on the basis of physiochemical and spectral analysis (IR, and 1H-NMR). All these newly synthesized compounds (IVa-l) were screened for their antimicrobial and antifungal activity. The compounds IVc, IVf, IVg, IVj, IVl showed the good antibacterial activity and IVc and IVj showed the moderate antifungal activity.