TRENDS OF PREVALENCE OF SYMPTOMS OF ATOPIC DERMATITIS IN CHILDREN (RESULTS OF PHASE III, ISAAC) IN A SINGLE ADMINISTRATIVE?TERRITORIAL REGION OF THE REPUBLIC OF BELARUS (GRODNO REGION)

The assessment of the dynamics of prevalence of symptoms of atopic dermatitis in children aged 6-7 years (n=1,000) and 13?14 years (n=1,091) during 2008-2014 years according to the ISAAC program (phase III) was carried out. In children of younger age within 6 years the prevalence of symptoms of the itchy rash for the last 12 months decreased from 8.25%, CI: 6.6?10.3% to 5.4%, CI: 4.2?6.98% (p=0.0149). In older children the prevalence of symptoms of damaging rash increased in the following places: elbow bends, under the knees, front ankles, under the buttocks, round the neck, eyes, ears from 0.5%, CI: 0.2-1% to 2.6%, CI: 1.8?3.7% (p=0.0005) and depended on the age of rash emergence: under 2 years ? from 0.3%, CI: 0.1?0.9% to 1.6%, CI: 0.98?2.5% (p=0.0088), from 2 to 4 years ? from 0.4%, CI: 0.2?1% to 1.65%, CI: 1.05?2.6% (p=0.0073), in children older than 5 years ?from 1.2%, CI: 0.6?2% to 2.4%, CI: 1.6?3.5% (p=0.0382). In boys of 6-7 years the prevalence of the diagnosis of eczema, neurodermatitis, atopic dermatitis established at some time before decreased from 9.7%, CI: 7.2?13% to 5.05%, CI: 3.4?7.35% (p=0.0066), in girls the prevalence of symptoms of the itching rash for the previous 12 months decreased from 7.7%, CI: 6.2?11.5% to 4.95%, CI: 3.4?7.2% (p=0.0308); symptoms of skin damage with the itching rash in places, typical for atopic dermatitis, decreased from 5.8%, CI: 4.4?9.1% to 3.4%, CI: 1.8?4.8% (p=0.0326). In boys aged 13?14 years the prevalence of symptoms of skin damage with the itching rash in places, typical for atopic dermatitis, increased from 0.24%, CI: 0.04?1.2% to 1.9%, CI: 1.3?6% (p=0.0258), in girls ? from 0.8%, CI: 0.3?2% to 3.05%, CI: 1.95?4.7% (p=0.0187). Long-term trends of prevalence of symptoms of atopic dermatitis on the territory of Grodno region are caused by the action of a number of factors which identification requires further research.