Depression Management during the Presence of Pain: An Overview

Background: Depression and anxiety are frequently associated with increased risk of medical problems. Severity of these problems varies from persistent pain to severe cardiovascular illness. The pathophysiology of chronic pain and depression overlap in the noradrenergic and seratonergic pathways. Antidepressants, especially dual acting which affect both pathways, are a frequent and effective choice of treatment for chronic pain. Although the coexistence of depression and pain, the treatment differs in terms of depression pain comorbidity and painful symptoms in depression. The aim of this study is to discover and integrate the data about pain. Methods: We have searched the literature from databases with the keywords “pain”, “depression” and “painful symptoms”. The search was limited to human studies of adults published in English. Because of the large number of studies a second search was required. The extracted data that have on consensus are taken.10 clinical trial, 3 reviews and 2 metaanalysis that all reviewers agreed have scoped. Results: We found evidences of strong relationship between pain perception and depression. Conclusion: The painful symptoms of depression and pain syndromes associated with depression must clearly be identified. Duloxetine has studied extensively and found to be effective in depression. Further studies with different drugs are required.